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  • Find Jobs in Germany: Job Search - Expat Guide to

    2021-9-5u2002·u2002Browse our listings to find jobs in Germany for expats, including jobs for English speakers or those in your native language.

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  • Dual gene therapy with extracellular superoxide dismutase ...

    2007-1-5u2002·u2002ROS scavengers include catalase and superoxide dismutase (SOD). SOD dismutes superoxide to hydrogen peroxide (H 2 O 2) and catalase detoxifies the H 2 O 2 to H 2 O and O 2. In a prior study, we targeted a single ROS, hydrogen peroxide, for detoxification by catalase gene inoculationn . It reduced demyelination of the optic nerve by 38%.

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  • Measurement of superoxide dismutase, catalase and ...

    2009-12-17u2002·u2002A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial ...

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  • Superoxide Dismutase Assay Kit - Cayman Chemical

    Significant amounts of superoxide dismutase (SOD) in cellular and extracellular environments are crucial for the prevention of diseases linked to oxidative stress. Mutations in SOD account for approximately 20% of familial amyotrophic lateral sclerosis (ALS) cases.

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  • The activity of superoxide dismutases (SODs) at the early ...

    2018-3-20u2002·u2002Unbound tetrapyrroles, i.e. protochlorophyllide (Pchlide), chlorophyllide and chlorophylls, bring the risk of reactive oxygen species (ROS) being generated in the initial stages of angiosperm deetiolation due to inefficient usage of the excitation energy for photosynthetic photochemistry. We analyzed the activity of superoxide dismutases (SODs) in etiolated wheat …

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  • Purification and characterization of superoxide dismutase ...

    2001-2-1u2002·u20021.. IntroductionThe superoxide radical (O 2 −) has received recent attention due to its role as an agent of oxygen toxicity to cells.The O 2 − radical is an intermediate reduction product of oxygen produced by a variety of biological reactions (Fridovich, 1995).The cytotoxicity of this free radical is well documented (McCord, 1993).The presence of superoxide dismutase (SOD) …

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  • Superoxide Dismutase, Lipid Peroxidation, and Bell-Shaped ...

    2008-8-6u2002·u2002Cellular metabolism generates the cytotoxic superoxide free radical, O 2 · −, and a family of enzymes called superoxide dismutases (SOD) protects us from O 2 · − by catalyzing its conversion to O 2 and H 2 O 2.Superoxide production increases in a wide variety of pathological states, especially those involving inflammation or ischemic injury.

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  • Combined effect of L-arginine and superoxide dismutase on ...

    To investigate the function of nitric oxide (a major endothelium-derived relaxing factor) in cerebral arteries after subarachnoid hemorrhage (SAH) in vivo, several nitric oxide-related substances were administered to dogs that had undergone double SAH.These included L-arginine (a substrate for the formation of nitric oxide), N G-monomethyl-L-arginine (L-NMMA, an analog of L-arginine that …

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  • Orally available Mn porphyrins with superoxide dismutase ...

    2009-6-6u2002·u2002Superoxide dismutase/catalase mimetics, such as salen Mn complexes and certain metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have been implicated in the pathogenesis of many serious diseases. Both classes of mimetic are protective in animal models of oxidative stress. However, only AEOL11207 and EUK-418, two uncharged Mn …

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  • Superoxide Dismutase1 Levels in North Indian Population ...

    Aim. The aim of the study was to estimate the levels of superoxide dismutase1 (SOD1) in patients of age-related macular degeneration (AMD) and examine the role of oxidative stress, smoking, hypertension, and other factors involved in the pathogenesis of AMD. Methods. 115 AMD patients and 61 healthy controls were recruited for this study.

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  • Biochemistry reagent, Clinical chemistry reagent - All ...

    clinical chemistry reagent. XSYS0046, BLT20001, BLT20002. Clinical Significance: The ASO test is primarily used to help determine a recent strep infection with group A Streptococcus. It causes: Glomerulonephritis, a form of kidney disease Rheumatic fever in a …

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  • Impact of Superoxide Dismutase Mimetic AEOL 10150 on

    2016-3-18u2002·u2002Endothelin-1 is a potent vasoconstrictor and mitogenic peptide involved in the regulation of vasomotor tone and maintenance of blood pressure. Oxidative stress activates the endothelin system, and is implicated in pulmonary and cardiovascular diseases including hypertension, congestive heart failure, and atherosclerosis. Superoxide dismutase mimetics designed with the aim of treating …

    Get Price
  • Cinnamomum burmannii (Nees & T. Nees) Blume and ...

    2020-7-23u2002·u2002superoxide dismutase. Introduction Hyperlipidemia is a medical condition character - ized by the elevation of any or all lipid profiles and/or lipoproteins in the blood and is also called hypercho-lesterolemia or hyperlipoproteinemia [1,2]. Although elevated low-density lipoprotein cholesterol (LDL-C)

    Get Price
  • Superoxide Dismutase, Lipid Peroxidation, and Bell-Shaped ...

    2008-8-6u2002·u2002Cellular metabolism generates the cytotoxic superoxide free radical, O 2 · −, and a family of enzymes called superoxide dismutases (SOD) protects us from O 2 · − by catalyzing its conversion to O 2 and H 2 O 2.Superoxide production increases in a wide variety of pathological states, especially those involving inflammation or ischemic injury.

    Get Price
  • OMIM Entry - * 147450 - SUPEROXIDE DISMUTASE 1; SOD1

    The SOD1 gene encodes superoxide dismutase-1 (EC 1.15.1.1), a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide, thus providing a defense against oxygen toxicity (Niwa et al., 2007).Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme; the SOD1 gene maps to chromosome 21q22 (Sherman et al., 1983).

    Get Price
  • Biomedicines

    Inflammatory eye diseases remain the most common clinical problem in ophthalmology. The secondary processes associated with inflammation, such as overproduction of reactive oxygen species (ROS) and exhaustion of the endogenous antioxidant system, frequently lead to tissue degeneration, vision blurring, and even blindness. Antioxidant enzymes, such as copper–zinc superoxide dismutase (SOD1 ...

    Get Price
  • The Functional Role of MnSOD as a Biomarker of Human ...

    Reactive oxygen species (ROS) are generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. This work describes the role of the manganese superoxide dismutase (MnSOD) as a biomarker of different human diseases and proposes a new therapeutic application for the prevention of cancer and its treatment. The paper also describes how a new form of human MnSOD …

    Get Price
  • Amazon.com: Biotics Research Cytozyme Thy Neonatal

    Neonatal Thymus Concentrate (bovine), Superoxide Dismutase (from vegetable culture†), Catalase (from vegetable culture†). †Specially grown, biologically active vegetable culture containing naturally associated phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme ...

    Get Price
  • Superoxide Dismutase1 Levels in North Indian Population ...

    Aim. The aim of the study was to estimate the levels of superoxide dismutase1 (SOD1) in patients of age-related macular degeneration (AMD) and examine the role of oxidative stress, smoking, hypertension, and other factors involved in the pathogenesis of AMD. Methods. 115 AMD patients and 61 healthy controls were recruited for this study.

    Get Price
  • Placental superoxide dismutase 3 mediates benefits of ...

    Kusuyama et al. define a novel mechanism for placental transmission of improved metabolic health to offspring. SOD3 is identified as an exercise-induced and vitamin D-regulated placenta-derived protein that improves glucose homeostasis in offspring. SOD3 activates an AMPK/TET signaling axis resulting in epigenetic changes to metabolic genes in offspring liver.

    Get Price
  • Increased 3‐nitrotyrosine and oxidative damage in mice ...

    Abstract Mutations in copper/zinc superoxide dismutase (SOD1) cause a subset of cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS). Transgenic mice that express these point m...

    Get Price
  • A superoxide dismutase/catalase mimetic nanomedicine for ...

    2016-10-1u2002·u2002Superoxide, peroxide, and hydroxyl radical are among the major components of ROS . Most intracellular ROS are derived from superoxide that is generated by the reduction of oxygen. Dismutation of superoxide by superoxide dismutase (SOD) generates hydrogen peroxide, which may be reduced to hydroxyl radical or decomposed into water by catalase.

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  • Orally available Mn porphyrins with superoxide dismutase ...

    2009-6-6u2002·u2002Superoxide dismutase/catalase mimetics, such as salen Mn complexes and certain metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have been implicated in the pathogenesis of many serious diseases. Both classes of mimetic are protective in animal models of oxidative stress. However, only AEOL11207 and EUK-418, two uncharged Mn …

    Get Price
  • Cinnamomum burmannii (Nees & T. Nees) Blume and ...

    2020-7-23u2002·u2002superoxide dismutase. Introduction Hyperlipidemia is a medical condition character - ized by the elevation of any or all lipid profiles and/or lipoproteins in the blood and is also called hypercho-lesterolemia or hyperlipoproteinemia [1,2]. Although elevated low-density lipoprotein cholesterol (LDL-C)

    Get Price
  • Selective inhibition of aggregation/fibrillation of bovine ...

    2017-2-16u2002·u2002Serum albumin is the transport protein of the blood circulatory system that bind and hence act as a carrier for a wide variety of exo- and endogenous ligands [].BSA is made up of a single polypeptide chain consisting of 583 amino acids, arranged into three homologous domains which is primarily made up of alpha helices as the secondary structure with some turns and …

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  • Superoxide Dismutase, Lipid Peroxidation, and Bell-Shaped ...

    2008-8-6u2002·u2002Cellular metabolism generates the cytotoxic superoxide free radical, O 2 · −, and a family of enzymes called superoxide dismutases (SOD) protects us from O 2 · − by catalyzing its conversion to O 2 and H 2 O 2.Superoxide production increases in a wide variety of pathological states, especially those involving inflammation or ischemic injury.

    Get Price
  • The role of superoxide dismutase (SOD) in skin disorders ...

    2014-3-14u2002·u2002Kwon M-J, Kim B, Lee YS, Kim T-Y (2012) Role of superoxide dismutase 3 in skin inflammation. J Dermatol Sci 67(2):81–87. CAS Article Google Scholar 10. Ookawara T, Imazeki N, Matsubara O et al (1998) Tissue distribution of immunoreactive mouse extracellular superoxide dismutase. Am J Physiol 275(3 Pt 1):C840–847

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  • Viral gene delivery of superoxide dismutase attenuates ...

    2002-2-22u2002·u2002Hydrophobic bile acids lead to generation of oxygen free radicals in mitochondria. Accordingly, this study investigated if gene delivery of superoxide dismutase …

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  • Generation of superoxide anion by brain endothelial cell ...

    Bovine brain endothelial cells (EC) that were isolated and propagated in pure culture had increased ( 20‐fold) levels of xanthine oxidase and xanthine dehydrogenase activity compared to whole brain homogenate. Brain EC also released superoxide anion (O) in to the extracellular medium.

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  • Products - Gr8water

    Products The Water Factory Atmospheric Water Generator… Making water like nature does. GR8 Water products are created to provide a cost-effective green alternative to obtaining pure, safe drinking water. The Water Factory is 'Made in USA'. GR8 Water operations management assures the highest level of quality control and workmanship in the industry.

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  • Lifesciences Laboratory Research Kits, Reagents ...

    We are trusted supplier of lifesciences research and development products. Our product profile include ELISA Kits & Biochemical Assays, Recombinant Proteins, Enzymes, DNA-RNA Kits, Antibody of Polyclonal, Monoclonal and Secondary type, Peptides, Amino Acids, Hormones, Inhibitors, Real Time End Point PCR Kits, DNA Purification Kits, RNA Purification Kits, Plasmids, Vectors, …

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  • Impact of Superoxide Dismutase Mimetic AEOL 10150 on

    2016-3-18u2002·u2002Endothelin-1 is a potent vasoconstrictor and mitogenic peptide involved in the regulation of vasomotor tone and maintenance of blood pressure. Oxidative stress activates the endothelin system, and is implicated in pulmonary and cardiovascular diseases including hypertension, congestive heart failure, and atherosclerosis. Superoxide dismutase mimetics designed with the aim of treating …

    Get Price
  • Cinnamomum burmannii (Nees & T. Nees) Blume and ...

    2020-7-23u2002·u2002superoxide dismutase. Introduction Hyperlipidemia is a medical condition character - ized by the elevation of any or all lipid profiles and/or lipoproteins in the blood and is also called hypercho-lesterolemia or hyperlipoproteinemia [1,2]. Although elevated low-density lipoprotein cholesterol (LDL-C)

    Get Price
  • Superoxide Dismutase, Lipid Peroxidation, and Bell-Shaped ...

    2008-8-6u2002·u2002Cellular metabolism generates the cytotoxic superoxide free radical, O 2 · −, and a family of enzymes called superoxide dismutases (SOD) protects us from O 2 · − by catalyzing its conversion to O 2 and H 2 O 2.Superoxide production increases in a wide variety of pathological states, especially those involving inflammation or ischemic injury.

    Get Price
  • OMIM Entry - * 147450 - SUPEROXIDE DISMUTASE 1; SOD1

    The SOD1 gene encodes superoxide dismutase-1 (EC 1.15.1.1), a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide, thus providing a defense against oxygen toxicity (Niwa et al., 2007).Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme; the SOD1 gene maps to chromosome 21q22 (Sherman et al., 1983).

    Get Price
  • Biomedicines

    Inflammatory eye diseases remain the most common clinical problem in ophthalmology. The secondary processes associated with inflammation, such as overproduction of reactive oxygen species (ROS) and exhaustion of the endogenous antioxidant system, frequently lead to tissue degeneration, vision blurring, and even blindness. Antioxidant enzymes, such as copper–zinc superoxide dismutase (SOD1 ...

    Get Price
  • The Functional Role of MnSOD as a Biomarker of Human ...

    Reactive oxygen species (ROS) are generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. This work describes the role of the manganese superoxide dismutase (MnSOD) as a biomarker of different human diseases and proposes a new therapeutic application for the prevention of cancer and its treatment. The paper also describes how a new form of human MnSOD …

    Get Price
  • Amazon.com: Biotics Research Cytozyme Thy Neonatal

    Neonatal Thymus Concentrate (bovine), Superoxide Dismutase (from vegetable culture†), Catalase (from vegetable culture†). †Specially grown, biologically active vegetable culture containing naturally associated phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme ...

    Get Price
  • Superoxide Dismutase1 Levels in North Indian Population ...

    Aim. The aim of the study was to estimate the levels of superoxide dismutase1 (SOD1) in patients of age-related macular degeneration (AMD) and examine the role of oxidative stress, smoking, hypertension, and other factors involved in the pathogenesis of AMD. Methods. 115 AMD patients and 61 healthy controls were recruited for this study.

    Get Price
  • Placental superoxide dismutase 3 mediates benefits of ...

    Kusuyama et al. define a novel mechanism for placental transmission of improved metabolic health to offspring. SOD3 is identified as an exercise-induced and vitamin D-regulated placenta-derived protein that improves glucose homeostasis in offspring. SOD3 activates an AMPK/TET signaling axis resulting in epigenetic changes to metabolic genes in offspring liver.

    Get Price
  • Increased 3‐nitrotyrosine and oxidative damage in mice ...

    Abstract Mutations in copper/zinc superoxide dismutase (SOD1) cause a subset of cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS). Transgenic mice that express these point m...

    Get Price
  • Wild-type Cu/Zn-superoxide dismutase is misfolded in ...

    2019-11-19u2002·u2002A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins are susceptible to misfolding and abnormally accumulated in spinal cord, which is most severely affected in ALS. It, however, remains quite controversial whether misfolding of wild-type SOD1 is involved in more …

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  • Variations in oxidative stress and antioxidant defense ...

    Antioxidant defense comprising antioxidant enzymes (Superoxide dismutase and Catalase) and nonenzymatic antioxidants (Ascorbic acid, Uric acid, and GSH) were investigated in this study. Although there was an increasing trend in SOD activity in both liver and brain tissues of hibernating toads compared to active toads it was found nonsignificant ...

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  • Localization and Role of Manganese Superoxide

    2006-10-20u2002·u2002Abstract. Superoxide dismutase (SOD) catalyzes the transformation of superoxide to molecular oxygen and hydrogen peroxide. Of the four known SOD isoforms, distinguished by their metal cofactor (iron, manganese [Mn], copper/zinc, nickel), MnSOD is the dominant form in the diatom Thalassiosira pseudonana.We cloned the MnSOD gene, sodA, using the expression vector pBAD, …

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  • Vitamin C attenuates vancomycin induced nephrotoxicity ...

    The non-homeostatic states 'oxidative stress' is caused by the over production of ROS . Superoxide dismutase SOD2 can effectively convert superoxide (one type of ROS) to less active hydrogen peroxide, the loss of SOD2 activity will lead to some metabolic diseases . ROS generated in cell can damage cellular macromolecules, including nucleic ...

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  • Superoxide increases angiotensin II AT1 receptor

    Superoxide increases angiotensin II AT1 receptor function in human kidney-2 cells Mohammad Saleem, Indira Pokkunuri and Mohammad Asghar Pharmacological and Pharmaceutical Sciences, Heart and ...

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  • Virbac

    Hough, M. A. & Hasnain, S. S. Structure of Fully Reduced Bovine Copper Zinc Superoxide Dismutase at 1.15 Å. Structure 11, 937–946 (2003). Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG and Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science, 179 …

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  • Pine Pollen Testosterone - 5 ways this herb jacks up your ...

    2018-6-21u2002·u2002Pine pollen contains natural arginine that your body will put to use to build stronger erections. Arginine is good for your sperm too, improving sperm motility, general fertility, and cranking up sperm production. The result is a better erection with more (and better) swimmers. Superoxide dismutase (SOD)

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  • R&D Systems: Products & Services for Cell Biology Research

    R&D Systems is a global resource for cell biology. Find quality proteins, antibodies, ELISA kits, laboratory reagents, and tools.

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  • Frontiers

    2021-2-11u2002·u2002Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease, neurodegeneration and cancer. Despite decades of research dedicated to understanding aging, the mechanisms underlying the aging process remain incompletely understood. The widely-accepted free radical theory of aging (FRTA) proposes that the accumulation of oxidative damage caused by …

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  • Targeting mitochondrial reactive oxygen species as novel ...

    2013-2-25u2002·u2002There are multiple sources of reactive oxygen species (ROS) in the cell. As a major site of ROS production, mitochondria have drawn considerable interest because it was recently discovered that mitochondrial ROS (mtROS) directly stimulate the production of proinflammatory cytokines and pathological conditions as diverse as malignancies, autoimmune diseases, and cardiovascular …

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