N6-Methyladenosine on mRNA facilitates a phase
2021-7-12u2002·u2002N 6-Methyladenosine (m 6 A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m 6 A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is the essential m 6 A reader in myeloid leukemia from a genome-wide CRISPR screen and that m 6 A is required for YTHDC1 to undergo liquid-liquid …
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