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2004-7-1u2002·u2002To maintain O 2 homeostasis, a number of genes are up-regulated at low O 2 tension via signaling that activates transcription (eg, via hypoxia-inducible transcription factor 1 [HIF-1]). HIF-1 is crucial in sensing hypoxia and integrating the adaptive response via transcription of O 2-sensitive genes. 12,13 The physiologic factors that link O 2 availability to transcription relate broadly to ...
Get Price1 Superoxide Dismutase. Superoxide dismutase (SOD) is a copper- and zinc-containing enzyme that was first isolated from cattle blood (McCord and Fridovich, 1969). It promotes the dismutation of two O 2 − molecules to H 2 O 2 and O 2 (Fig. 7.5).
Get Price2017-7-21u2002·u2002Leishmaniasis is one of the leading globally neglected diseases, affecting millions of people worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic promastigotes to invade mammalian hosts, differentiate into amastigotes, and replicate inside macrophages. To counter the hostile oxidative environment inside macrophages, these protozoans contain anti-oxidant ...
Get PriceMutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with familial amyotrophic lateral sclerosis (ALS). ... two superoxide dismutases whereas bovine heart ...
Get PriceA dedicated Superoxide Dismutase quality control for use in the routine monitoring of the Randox Ransod assay on clinical chemistry analysers.
Get Price1983-12-1u2002·u2002Alkaline dimethylsulfoxide as a superoxide anion-generating system in association with cytochrome c as a superoxide anion-indicating scavenger has been used to develop a new assay for superoxide dismutase. The assay is sensitive (one unit of enzymatic activity is provided by 110 ng of purified copper-containing superoxide dismutase) and highly specific.
Get Price2020-1-14u2002·u2002Chronic hypoxia leads to pathologic remodeling of the pulmonary vasculature and pulmonary hypertension (PH). The antioxidant enzyme extracellular superoxide dismutase (SOD3) protects against ...
Get Price2018-3-20u2002·u2002Unbound tetrapyrroles, i.e. protochlorophyllide (Pchlide), chlorophyllide and chlorophylls, bring the risk of reactive oxygen species (ROS) being generated in the initial stages of angiosperm deetiolation due to inefficient usage of the excitation energy for photosynthetic photochemistry. We analyzed the activity of superoxide dismutases (SODs) in etiolated wheat (Triticum aestivum) leaves …
Get Price2020-8-24u2002·u20021. Introduction. Lactoferrin, an 80 kDa iron-binding glycoprotein belonging to the family of transferrin proteins, was first isolated in 1939 from cow's milk [] and in 1960 was shown to be the main iron-binding protein in human milk [].Lactoferrin is also found in mucosal secretions such as tears, saliva, vaginal mucus, seminal plasma, nasal and bronchial secretions, bile, gastrointestinal ...
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