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  • Interactions of Lecithinized Superoxide Dismutase with ...

    2014-7-1u2002·u2002Superoxide dismutase covalently bound to four lecithin molecules (PC-SOD) is known to be retained in circulating blood for a prolonged period and has a high affinity for cells, resulting in beneficial therapeutic effects in animal disease models. In this study, we evaluated the interaction of PC-SOD with biological components, such as serum ...

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  • Bovine Superoxide Dismutase – Innovative Research

    Bovine Superoxide Dismutase from Innovative Research has been prepared from bovine red blood cells and chromatographically purified. This is a dialyzed, lyophilized powder. Superoxide Dismutase is an enzyme that helps to partition the superoxide radical (which is produced as a by-product of oxygen metabolism) into ordi

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  • Superoxide dismutase-3 promotes full expression of the EPO ...

    2004-7-1u2002·u2002To maintain O 2 homeostasis, a number of genes are up-regulated at low O 2 tension via signaling that activates transcription (eg, via hypoxia-inducible transcription factor 1 [HIF-1]). HIF-1 is crucial in sensing hypoxia and integrating the adaptive response via transcription of O 2-sensitive genes. 12,13 The physiologic factors that link O 2 availability to transcription relate broadly to ...

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  • Superoxide Dismutase (SOD) Detection Kit

    Superoxide dismutase (SOD), which catalyzes the dismutation of the superoxide anion (O 2.-) into hydrogen peroxide and molecular oxygen, is one of the most important antioxidative enzymes. In mammals, cytosolic SOD has a greenish color and consists of two subunits, one containing copper and the other zinc (Cu/Zn-SOD).

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  • Superoxide Dismutase: AN ENZYMIC FUNCTION FOR ...

    Superoxide Dismutase. : AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN) An enzyme which catalyzes the dismutation of superoxide radicals (O 2 · - + O 2 · - + 2H + → O 2 + H 2 O 2) has been purified by a simple procedure from bovine erythrocytes. This enzyme, called superoxide dismutase, contains 2 eq of copper per mole of enzyme.

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  • Age‐ and sex‐specific reference intervals for superoxide ...

    2021-7-17u2002·u2002The aim of this study was to establish RIs for clinically important markers including superoxide dismutase (SOD), serum copper, zinc, calcium, magnesium, and phosphate in a cohort of healthy Iranian adults. Materials. A subsample from MASHAD cohort study was used to assess serum SOD, copper, zinc, calcium, magnesium and phosphate.

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  • Further Characterization of Bovine Superoxide Dismutase ...

    Superoxide dismutase has been purified from bovine heart by a procedure which was previously developed for the isola- tion of this enzyme from bovine erythrocytes.

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  • Superoxide Dismutase Archives - Randox Laboratories

    2016-10-20u2002·u2002Superoxide Dismutase. Superoxide is a by-product of oxygen metabolism and is one of the most damaging free radicals in the body as it can cause cell damage. Superoxide Dismutase (SOD) is an enzyme which catalyses the breakdown of superoxide into a less damaging oxygen or hydrogen peroxide.

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  • A microtiter plate assay for superoxide dismutase using a ...

    2.1. Materials WST-1 was obtained from Dojindo Laboratories (Kumamoto, Japan). Bovine erythrocyte superoxide dismutase, catalase, cytochrome c, xanthine oxidase were ... Fresh blood from healthy

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  • Interaction of bovine erythrocyte superoxide dismutase

    2020-12-1u2002·u2002Reduction of erythrocyte catalase and superoxide dismutase activities in male inhabitants of a cadmium-polluted area in Jinzu river basin, Japan. Toxicology Letters 2004, 151 (3), 451-457.

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  • Superoxide Dismutase (Ransod) Quality Control - Randox

    A dedicated Superoxide Dismutase quality control for use in the routine monitoring of the Randox Ransod assay on clinical chemistry analysers.

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  • Extracellular but not cytosolic superoxide dismutase

    2013-5-24u2002·u2002Superoxide (O 2 •−) contributes to the development of cardiovascular disease.Generation of O 2 •− occurs in both the intracellular and extracellular compartments. We hypothesized that the gene transfer of cytosolic superoxide dismutase (SOD1) or extracellular SOD (SOD3) to blood vessels would differentially protect against O 2 •−-mediated endothelial-dependent dysfunction.

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  • Association among extracellular superoxide dismutase

    2021-4-20u2002·u2002Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD ...

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  • CAS No.9054-89-1,Dismutase, superoxide Suppliers,MSDS

    Superoxide dismutase. Min.Order: 1000 Gram FOB Price: USD $ 500.0-500.0/Gram chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

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  • PFOA and PFOS interact with superoxide dismutase and

    2019-8-1u2002·u20021. Introduction. Per- and polyfluoroalkyl substances (PFASs) are man-made compounds, which belong to a kind of persistent organic pollutants (POPs) (Byrne et al., 2017; Nian et al., 2019).PFASs are known for their antiwetting and surfactant properties and used in nonstick cookware, waterproof, breathable textiles, firefighting foams, and protective coatings for paper, food packing materials ...

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  • Extracellular Superoxide Dismutase Regulates Early

    2020-1-14u2002·u2002Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid.

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  • Post-exposure distribution of selenium and aluminum ions

    2018-10-3u2002·u2002The study was conducted to determine how aluminum (Al) and selenium (Se) ions alone and in combination affect superoxide dismutase (SOD) activity and to evaluate the distribution of these elements in the blood and the brain of laboratory mice. SOD activity in mouse brain was evaluated after single-time (within 24 h) and repeated (over 14 days) intraperitoneal (IP) injections of SeO32−, Al3 ...

    Get Price
  • Interactions of Lecithinized Superoxide Dismutase with

    Superoxide dismutase covalently bound to four lecithin molecules (PC-SOD) is known to be retained in circulating blood for a prolonged period and has a high affinity for cells, resulting in ...

    Get Price
  • Superoxide is the major reactive oxygen species regulating

    2009-5-1u2002·u2002Autophagy is involved in human diseases and is regulated by reactive oxygen species (ROS) including superoxide (O2•−) and hydrogen peroxide (H2O2). However, the relative functions of O2•− ...

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  • Interaction of bovine erythrocyte superoxide dismutase ...

    2020-12-1u2002·u2002Reduction of erythrocyte catalase and superoxide dismutase activities in male inhabitants of a cadmium-polluted area in Jinzu river basin, Japan. Toxicology Letters 2004, 151 (3), 451-457.

    Get Price
  • Materials and Methods - JSTOR

    Pharma Company (Tokyo, Japan). Bovine liver catalase, Cu/Zn-superoxide dismutase (SOD), ax-tocopherol, [-carotene, and zymosan were purchased from Sigma-Aldrich Japan Company (Tokyo, Japan). Other chemicals for experiments were purchased from Sigma-Aldrich Japan Company except for specific chemicals described in the text.

    Get Price
  • Bovine Red Blood Cells, Packed 100% Reference 8-17-10 ...

    Materials and methods. 2.1. Materials. Freshly pooled bovine red blood cells were purchased from Innovative Research (Novi, Michigan IC100-0410). Polyethylene glycol (Molecular weight: 2 kDa), Superoxide dismutase SOD... Tags: Animal Blood Cells, Bovine Red Blood Cells Packed 100%.

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  • Studies on the relationship between haemoglobin, copper ...

    2005-8-31u2002·u2002The relationship between haemoglobin, copper, ceruloplasmin, iron, and superoxide dismutase (SOD) activity in blood of Iranian fat-tailed sheep was studied. Blood samples were taken from the jugular vein of 128 clinically healthy Iranian fat-tailed sheep grouped according to their age (<6, 6–12, 12–24, 24–36 and >36 months) and sex. Age had a significant effect on blood concentrations of ...

    Get Price
  • Research Article Superoxide Dismutase 1 Nanozyme for ...

    2019-7-30u2002·u2002stability in both blood and brain, enhanced penetration through the blood-brain barrier, and, therefore, increased accumulationinbraintissues,incomparisonwithnon-cross-linked complexes and native enzyme [,, ]. In the current study, we demonstrate the advantages of topical instillations of superoxide dismutase in the form

    Get Price
  • Regulating Redox Balance Gene Expression in Healthy ...

    2021-6-7u2002·u2002in 11 healthy nonsmoker, teetotaller individuals subjected to a detailed dietary and lifestyle questionnaire who refrained from any multivitamin supplement or fortified food. Redox status was assessed by erythrocyte and plasma parameters together with related leukocyte mRNA (glutathione peroxidase [GPx], superoxide dismutase

    Get Price
  • Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6 ...

    2009-6-25u2002·u2002We hypothesized that the administration of the superoxide dismutase (SOD) mimetic Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) may reverse diabetes-induced erectile dysfunction. To ...

    Get Price
  • Changes in oxidative stress intensity in blood of tumor ...

    2016-9-15u2002·u2002blood plasma, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GP) in erythrocyte hemolysates were examined using methods [4-7]. The antioxidant effectiveness (E%) was calculated as a ratio of the concentration of TBA-active compounds in blood …

    Get Price
  • Protection of Bovine Mammary Epithelial Cells from ...

    The mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 -) induced OS in cultured bovine …

    Get Price
  • Roles of prostaglandin F2alpha and hydrogen peroxide in ...

    2012-10-26u2002·u2002Prostaglandin F2alpha (PGF) induces luteolysis in cow by inducing a rapid reduction in progesterone production (functional luteolysis) followed by tissue degeneration (structural luteolysis). However the mechanisms of action of PGF remain unclear. Reactive oxygen species (ROS) play important roles in regulating the luteolytic action of PGF. The local concentration of ROS is controlled …

    Get Price
  • Antioxidant Capacity and Superoxide Dismutase Activity in ...

    Superoxide dismutase activity in human blood plasma mirrored these reductions between prospectively collected samples from healthy controls (2.66 units/mg protein) and samples from heterozygote female carriers (1.91 units/mg protein), patients with AMN (1.39 units/mg protein; P = .01), and patients with cALD (0.8 units/mg protein; P < .01).

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  • Lactosylceramide-enriched glycosphingolipid signaling ...

    2002-8-15u2002·u2002As a positive control of superoxide generation, cells were incubated with 10 −7 M fMLP or 0.5% DMSO (as a solvent control) in bovine serum albumin–coated wells at 37°C for 30 minutes. Superoxide production was calculated by measurement of the superoxide dismutase–inhibitable reduction of cytochrome c at 550 nm.

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  • Association among extracellular superoxide dismutase ...

    2021-4-20u2002·u2002Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD ...

    Get Price
  • Superoxide dismutase activity and gene expression levels ...

    The antioxidant activities of superoxide dismutase 1 (SOD1) and SOD2, as well as the levels of the oxidant superoxide anion (SOA) and the micronutrients zinc (Zn), copper (Cu) and manganese (Mn), were assayed in plasma, whole blood and placental tissue of non‑pregnant (NP), healthy pregnant (HP) women and recurrent miscarriage (RM) patients.

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  • Regulation of Cu-Zn superoxide dismutase on SCN2A in

    In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn SOD in SH-SY5Y cells were examined. SCN2A expression and the concentration of Cu-Zn SOD in the cerebral cortexes of patients with primary and ...

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  • Targeted Delivery of Superoxide Dismutase by Chemical ...

    2015-8-27u2002·u2002Objective To improve the half-life and tissue targeting of superoxide dismutase (SOD) in suppressing reactive oxygen species (ROS)-mediated injury, SOD was chemically modified with N,N,N-trimethyl chitosan chloride (TMC) to generate TMC-SOD. Methods In this study, the pharmacokinetics of TMC-SOD had been studied. 125I-radiolabeled TMC-SOD conjugate was administered to healthy …

    Get Price
  • The biophysics of superoxide dismutase-1 and

    2021-8-2u2002·u2002A source of copper in blood. The first age of SOD1 discovery began two centuries ago with the work of chemists, such as Christian Friedrich Bucholz, who found copper to be a constituent of plant and animal tissue. Subsequently, in the latter half of the 19 th century, came the discovery of zinc in biological materials. The copper and zinc under ...

    Get Price
  • Post-exposure distribution of selenium and aluminum ions ...

    2018-10-3u2002·u2002The study was conducted to determine how aluminum (Al) and selenium (Se) ions alone and in combination affect superoxide dismutase (SOD) activity and to evaluate the distribution of these elements in the blood and the brain of laboratory mice. SOD activity in mouse brain was evaluated after single-time (within 24 h) and repeated (over 14 days) intraperitoneal (IP) injections of SeO32−, Al3 ...

    Get Price
  • Associations between superoxide dismutase,

    2019-4-15u2002·u2002Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults. This is a community-based cohort study of 2224 participants (women:1227, median age: …

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  • Frontiers

    2021-2-9u2002·u2002Native mass spectrometry has emerged as a powerful tool for structural biology as it enables the evaluation of molecules as they occur in their physiological conditions. Ion mobility spectrometry-mass spectrometry (IMS-MS) has shown essential in these analyses as it allows the measurement of the shape of a molecule, denoted as its collision cross section (CCS), and mass.

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  • Association among extracellular superoxide dismutase ...

    2021-4-20u2002·u2002Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD ...

    Get Price
  • The biophysics of superoxide dismutase-1 and

    2021-8-2u2002·u2002A source of copper in blood. The first age of SOD1 discovery began two centuries ago with the work of chemists, such as Christian Friedrich Bucholz, who found copper to be a constituent of plant and animal tissue. Subsequently, in the latter half of the 19 th century, came the discovery of zinc in biological materials. The copper and zinc under ...

    Get Price
  • Associations between superoxide dismutase,

    2019-4-15u2002·u2002Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults. This is a community-based cohort study of 2224 participants (women:1227, median age: …

    Get Price
  • (Bi)sulfite Oxidation by Copper,Zinc-Superoxide Dismutase ...

    2010-7-1u2002·u2002Distribution of 35 S in the blood and its excretion in urine dogs exposed to 35 SO 2. Arch Environ Health 22(3):389-395 4100716. Crossref, Medline, Google Scholar; Zhang H, Joseph J, Felix C, Kalyanaraman B. 2000. Bicarbonate enhances the hydroxylation, nitration, and peroxidation reactions catalyzed by copper, zinc superoxide dismutase.

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  • Targeted Delivery of Superoxide Dismutase by Chemical ...

    2015-8-27u2002·u2002Objective To improve the half-life and tissue targeting of superoxide dismutase (SOD) in suppressing reactive oxygen species (ROS)-mediated injury, SOD was chemically modified with N,N,N-trimethyl chitosan chloride (TMC) to generate TMC-SOD. Methods In this study, the pharmacokinetics of TMC-SOD had been studied. 125I-radiolabeled TMC-SOD conjugate was administered to healthy …

    Get Price
  • Identification of biomarkers for the antiangiogenic and ...

    2008-2-5u2002·u2002Superoxide dismutase 1 activity was measured as described in Materials and Methods. ( B ) A single dose of ATN-224 inhibits the SOD activity in plasma in a time-dependent manner.

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  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2019-9-9u2002·u2002Excessive reactive oxygen species Revised abstract, especially superoxide anion (O 2 •−), play important roles in the pathogenesis of many cardiovascular diseases, including hypertension and atherosclerosis.Superoxide dismutases (SODs) are the major antioxidant defense systems against O 2 •−, which consist of three isoforms of SOD in mammals: the cytoplasmic Cu/ZnSOD (SOD1), the ...

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  • SOD Assay Kit-WST - Dojindo Molecular Technologies, Inc.

    SOD or SOD-like Activity Detection ∼ Feature ∼ 1. WST-1 based SOD inhibition assay 2. Colorimetric microplate measurement 3. Measures 100% inhibition by SOD 4. pH-independent IC50 determination 5. Low background noise measurement Contents of the Kit: 500 tests Storage Condition: 0-5°C Shipping Condition: with blue ice Required Equipment and Materials Microplate reader with 450 nm filter ...

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  • Semenogelin, the Main Protein of Semen Coagulum,

    nostics) and radiographic films (Fuji, Minami-Ashigara, Japan) were used for immunodetection of phosphotyrosine-containing proteins. All other chemicals were at least of reagent grade. Fetal cord blood, generously provided by the blood bank at the Royal Victoria Hospital (Montre´al, Que´bec), was centrifuged (1000 g for 10 minutes at 4 C).

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  • Oxidative Stress in Association with Metabolic Health and ...

    2021-6-28u2002·u2002Introduction . Obesity is one of the most important public health problems in the world. Among obese people, there are those who, apart from excessive body weight, do not exhibit other metabolic dysfunctions, have a lower risk of developing cardiovascular diseases (CVDs), and show lower mortality. According to the theory, they are referred as metabolically healthy obese (MHO), in contrast …

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  • Interaction of bovine erythrocyte superoxide dismutase ...

    2020-12-1u2002·u2002Reduction of erythrocyte catalase and superoxide dismutase activities in male inhabitants of a cadmium-polluted area in Jinzu river basin, Japan. Toxicology Letters 2004, 151 (3), 451-457.

    Get Price
  • Materials and Methods - JSTOR

    Pharma Company (Tokyo, Japan). Bovine liver catalase, Cu/Zn-superoxide dismutase (SOD), ax-tocopherol, [-carotene, and zymosan were purchased from Sigma-Aldrich Japan Company (Tokyo, Japan). Other chemicals for experiments were purchased from Sigma-Aldrich Japan Company except for specific chemicals described in the text.

    Get Price
  • Bovine Red Blood Cells, Packed 100% Reference 8-17-10 ...

    Materials and methods. 2.1. Materials. Freshly pooled bovine red blood cells were purchased from Innovative Research (Novi, Michigan IC100-0410). Polyethylene glycol (Molecular weight: 2 kDa), Superoxide dismutase SOD... Tags: Animal Blood Cells, Bovine Red Blood Cells Packed 100%.

    Get Price
  • Studies on the relationship between haemoglobin, copper ...

    2005-8-31u2002·u2002The relationship between haemoglobin, copper, ceruloplasmin, iron, and superoxide dismutase (SOD) activity in blood of Iranian fat-tailed sheep was studied. Blood samples were taken from the jugular vein of 128 clinically healthy Iranian fat-tailed sheep grouped according to their age (<6, 6–12, 12–24, 24–36 and >36 months) and sex. Age had a significant effect on blood concentrations of ...

    Get Price
  • Research Article Superoxide Dismutase 1 Nanozyme for ...

    2019-7-30u2002·u2002stability in both blood and brain, enhanced penetration through the blood-brain barrier, and, therefore, increased accumulationinbraintissues,incomparisonwithnon-cross-linked complexes and native enzyme [,, ]. In the current study, we demonstrate the advantages of topical instillations of superoxide dismutase in the form

    Get Price
  • Regulating Redox Balance Gene Expression in Healthy ...

    2021-6-7u2002·u2002in 11 healthy nonsmoker, teetotaller individuals subjected to a detailed dietary and lifestyle questionnaire who refrained from any multivitamin supplement or fortified food. Redox status was assessed by erythrocyte and plasma parameters together with related leukocyte mRNA (glutathione peroxidase [GPx], superoxide dismutase

    Get Price
  • Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6 ...

    2009-6-25u2002·u2002We hypothesized that the administration of the superoxide dismutase (SOD) mimetic Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) may reverse diabetes-induced erectile dysfunction. To ...

    Get Price
  • Changes in oxidative stress intensity in blood of tumor ...

    2016-9-15u2002·u2002blood plasma, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GP) in erythrocyte hemolysates were examined using methods [4-7]. The antioxidant effectiveness (E%) was calculated as a ratio of the concentration of TBA-active compounds in blood …

    Get Price
  • Protection of Bovine Mammary Epithelial Cells from ...

    The mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 -) induced OS in cultured bovine …

    Get Price
  • Roles of prostaglandin F2alpha and hydrogen peroxide in ...

    2012-10-26u2002·u2002Prostaglandin F2alpha (PGF) induces luteolysis in cow by inducing a rapid reduction in progesterone production (functional luteolysis) followed by tissue degeneration (structural luteolysis). However the mechanisms of action of PGF remain unclear. Reactive oxygen species (ROS) play important roles in regulating the luteolytic action of PGF. The local concentration of ROS is controlled …

    Get Price